San Francisco 49ers' star defensive end Nick Bosa is expected to miss multiple weeks due to a calf injury sustained during practice. The injury occurred during warm-ups on September 24, 2026, when Bosa was performing high-knee exercises. Head coach Kyle Shanahan confirmed that Bosa will be sidelined for "a few weeks," though the team has not yet decided whether to place him on injured reserve, which would require a minimum four-game absence. (nfl.com)
This setback adds to a series of injuries that have plagued the 49ers' defensive line. In addition to Bosa, the team has lost defensive tackle C.J. West to injured reserve and is without edge rusher Mykel Williams, who is still recovering from knee surgery. (washingtonpost.com)
Bosa's absence is significant for the 49ers' defense. Since being drafted second overall in 2019, he has been a cornerstone of the team's pass rush, earning multiple Pro Bowl selections and the NFL Defensive Player of the Year award in 2022. (en.wikipedia.org)
The 49ers will need to rely on other defensive linemen to fill the void left by Bosa's injury. Veterans Ogbo Okoronkwo and Keion White are expected to see increased playing time in the coming weeks. (nfl.com)
The team is hopeful for Bosa's swift recovery, aiming to have him back on the field as soon as possible to bolster their defensive efforts.