Kathleen Madigan is an American stand-up comedian and TV personality from St. Louis, Missouri. She is known mainly for her work on late-night talk shows including Last Comic Standing and Conan O'Brien's late night shows. She has made regular guest appearances on various comedy shows including The Tonight Show and The Late Late Show. Madigan has also released five stand-up specials since 2008. Her most recent special, Bothering Jesus, was released on Netflix in 2019. Madigan has won several awards for her stand-up comedy, including a nomination for Best Female Stand-up Comedian at the American Comedy Awards. In addition to stand-up, she has also written and performed for regular shows on Sirius radio.